Epigenetic Regulation of Immune Dysfunction

Dysfunction of the immune system is central to disease progression in cancer and chronic viral infection. The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. Our work lies at the interface of human immunology, systems biology, and functional epigenomics – merging clinical observations with mechanistic mouse studies to develop novel therapeutic strategies.

We gratefully acknowledge support of our research from the following organizations