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Epigenetic Regulation of Immune Dysfunction
Dysfunction of the immune system is central to disease progression in cancer and chronic viral infection. The Sen laboratory investigates the regulation of T cell dysfunction and explores epigenetic approaches for T cell engineering. Our work lies at the interface of human immunology, systems biology, and functional epigenomics – merging clinical observations with mechanistic mouse studies to develop novel therapeutic strategies.
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We gratefully acknowledge support of our research from the following organizations
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